Toil is a scalable, efficient, dynamic cross-platform pipeline management system written entirely in Python. Toil is being used by projects like the Treehouse childhood cancer initiative https://treehousegenomics.soe.ucsc.edu/ to create portable, scaleable and reproducible analyses.
Toil was used to process over 20,000 RNA-seq samples in under four days using a commercial cloud cluster of 32,000 preemptable compute cores. Toil can also run workflows described in Common Workflow Language and supports a variety of schedulers, such as Mesos, GridEngine, LSF, Parasol and Slurm. Toil runs in the cloud on Amazon Web Services, Microsoft Azure and Google Cloud. See the Toil website and Toil Github for details.