Faculty / Leadership

David Haussler Team Pic
David Haussler Scientific Director

David’s titles include:
Scientific Director UCSC Genomics Institute
Investigator Howard Hughes Medical Institute

David Haussler develops new statistical and algorithmic methods to explore the molecular function, evolution, and disease process in the human genome, integrating comparative and high-throughput genomics data to study gene structure, function, and regulation. As a collaborator on the international Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence. His team subsequently developed the UCSC Genome Browser, a web-based tool that is used extensively in biomedical research. He co-founded the Genome 10K project so science can learn from other vertebrate genomes, co-founded the Treehouse Childhood Cancer Project to enable international comparison of childhood cancer genomes, and is a co-founder of the Global Alliance for Genomics and Health (GA4GH), a coalition of the top research, health care, and disease advocacy organizations He is a member of the National Academy of Science and the American Academy of Arts & Science.

Benedict Patten Team Photo
Benedict Paten Director

I am a principal investigator, director of the Computational Genomics Lab and an associate research scientist within the UC Santa Cruz Genomics Institute. I have a PhD from Cambridge University and the European Molecular Biology Laboratory. I am trying to contribute to answering some big questions, e.g. how we became human?, how we relate genetically to each other and other species?, and how genomes relate to the states of health and disease? To attack these questions I love algorithms, computers and coffee.

 

Research Scientists

Jingchun Zhu Team
Jingchun Zhu Associate Research Scientist

I earned my Ph.D. in biological and medical informatics from UC San Francisco, and subsequently held a postdoctoral position in the Haussler Lab at UCSC, where I led the development of the UCSC Cancer Genomics Browser. I’m a project lead for UCSC’s Xena visual analysis tool. My interests include improving presentation of genomics data to increase clinician and researcher understanding of disease, creating modular and sharable web-based data visualizations and data hosting. I’m currently involved in UCSC Xena (xena.ucsc.edu), UCSC Cancer Genomics Browser, the Cancer Genome Atlas (TCGA), International Cancer Genomics Consortium (ICGC), Big Data to Knowledge (BD2K), and the Treehouse Childhood Cancer Initiative.

Melissa Cline Team
Melissa Cline Project Scientist

I earned my Ph.D. in computer science with a concentration in bioinformatics from UC Santa Cruz, and previously held research positions in interaction networks at the Pasteur Institute, and alternative splicing at UCSC. I’m interested in transcriptional and post-transcriptional regulation of gene and isoform expression, pediatric cancer genomics, and genetic variation. I’m currently working on the BRCA Challenge, Athena, Treehouse / CKCC, Toil/BD2K Genomics Core. I enjoy free time outdoors climbing mountains, backcountry skiing and mountain biking. I’m a member of the Tahoe Backcountry Ski Patrol, and Treasurer of Trips for Kids Santa Cruz.

Max Haussler Team
Maximilian Haeussler Research Scientist

I work on text mining and the UCSC Genome Browser. I’ve held research positions in text mining, sequence mining and Chip-seq pipelines at Manchester University, UK, and in zinc-fingers and repeats, genome annotation of sequence variants, and text mining at UC Santa Cruz. I hold an MS in computer science and business from the Universitaet Potsdam in Berlin, Germany, and a Ph.D. in developmental biology from CNRS Gif-sur-Yvette, one of the Paris locations of the French National Center for Scientific Research, where my dissertation research concerned Ciona intestinalis and cis-regulatory genome annotation and enhancer prediction. I’m interested in genome annotation and currently working on single-cell sequencing analysis pipelines for CIRM, various tracks of the UCSC Genome Browser including text, patents, and cancer. I enjoy all kinds of machines, and especially the programmable ones.

Software Engineers

Kevin Osborne Team
Kevin Osborn Technical Director of Software Development

I spent 20 years working as an engineering manager in the file server storage industry starting with CDROM, moving to network attached storage and finally to clustered file servers and distributed computing before coming to UCSC to work in genomics. I have a patent on network security abstraction and another on distributed server synchronization (in process). My current work is with the GA4GH team to produce industry standard genomics APIs. I have bachelor degrees in Computer Science from UCSC and another in Natural Resources from Humboldt State, as well as an MFA from Brooks Institute in Photography. In my spare time I teach photography workshops and work on my own fine art business. I am also a long time fencing club operator in Santa Cruz who is certified as a Prevot level instructor.

David Steinberg Team
David Steinberg Software Engineer

As a software developer with the Genomics Institute I have worked on enabling software systems for genomic analysis. My background is in software design for the web, visual analytics, and systems integration. I hold a BA in Philosophy from UCSC and am interested in how technology can be used to reduce human suffering.

Christopher Ketchum Avatar
Christopher Ketchum Software Engineer

I hold a B.A. in Computer Science from UCSC. I primarily work on Toil and related projects for the Analysis Core, continuing the work I did as an undergraduate research assistant for the Genomics Institute. My interests include functional programming, cloud computing, and big data.

Mary Goldman Team
Mary Goldman Design and Outreach Engineer

I hold a B.S. in Biology from UCSC and have been working in genomics for six years, both for the UCSC Genome Browser and the UCSC cancer research group. I design and prototype software tools for genomics research in addition to managing communication with scientific community, including conducting instructional workshops. I’m currently working on the BRCA Challenge, whose goal is to responsibly share breast cancer data on BRCA1/2 variants, and the UCSC Xena platform, a functional genomics browser that allows researchers to view their private data with data from large consortiums, like TCGA, in a secure, federated manner. In my free time I enjoy contra and zydeco dancing as well as hiking to alpine lakes and peaks.

Yohei Rosen Avatar
Yohei Rosen Visiting Graduate Student

I’m a rising fourth year MD candidate at NYU who is at UCSC on a Howard Hughes Medical Institute fellowship. I completed my BA in theoretical mathematics at UC Berkeley in 2012 focusing on algebra and topology and my MASt in mathematical statistics at Cambridge in 2013. At Berkeley, I also studied chemical biology which helped develop my interests in medicine and research. I work within the Human Genome Variation Map project; my current research interests involve developing mathematical structures to allow reasoning with respect to biological and medical problems. Outside of research, I enjoy drawing, cooking and canoeing.

Brian O'Connor
Brian O’Connor Technical Director of the Analysis Core

Dr. Brian O’Connor is the Technical Director of the UCSC Genomics Institute Analysis Core.  There he focuses on the development and deployment of large-scale, cloud-based systems for analyzing genomics data.  This includes the Toil workflow execution platform, which is designed to run genomic pipelines on a wide range of cloud environments including AWS, Azure, Google and OpenStack, and ADAM, a distributed genomics platform developed in collaboration with UC Berkeley.  He is also the co-chair of the Containers and Workflows task team of the Global Alliance for Genomics and Health (GA4GH) where he works on tool and workflow container standards.  Brian recently joined UCSC from the Ontario Institute for Cancer Research (OICR) where his previous projects included leading the technical implementation of cloud-based analysis systems for the PanCancer Analysis of Whole Genomes (PCAWG) effort, the creation of the Dockstore project (http://dockstore.org), and the development of the International Cancer Genome Consortium’s Data Portal (http://dcc.icgc.org).

Brian Craft Team
Brian Craft Software Engineer

I hold an M.S. in neuroscience from Brandeis University, and a B.S. in engineering and applied science from The California Institute of Technology. I’m interested in databases, data visualization, and functional programming. I’m currently working on UCSC Xena (xena.ucsc.edu) and the UCSC Cancer Genomics Browser.

Postdoctoral Scholars

Karen Miga Team
Karen Miga Postdoctoral Scholar

My research focuses on one of the most challenging and unexplored regions of the human genome, the millions of bases that span repeat-rich centromeres and heterochromatic DNA. During both my doctorate work with Hunt Willard at Duke University and postdoctoral position at the UC Santa Cruz, I have designed and implemented computational approaches to model and annotate repeat-rich satellite DNAs that define each centromere gap region. In addition to understanding the sequence content and organization within centromeric/pericentromeric regions, I am leading efforts to better understand how these sequences vary in the human population and how they contribute to cellular function.

 
 

Graduate Student Researchers

John Vivien
John Vivian Graduate Student Researcher

I’m a Ph.D. student in bioinformatics at UCSC, where I also earned an M.S. My research areas encompass statistical inference and machine learning. More generally, I’m interested in bioinformatics, statistical modeling, data visualization, cloud computing, big data, and machine learning. I’m currently working on Toil, pipeline development, and RNA-seq analysis. Away from the lab, I enjoy playing piano and drums, composing music, rock climbing, and reading.

Arjun Arkal Rao Team
Arjun Arkal Rao Graduate Student Researcher

I’m a Ph.D. student in biomolecular engineering at UCSC, where I study the immune response to cancers and I’m working on a pipeline to predict potential tumor specific T-cell Receptor (TCR) epitopes as targets for immunotherapy. I hold a B.E. in biotechnology from the PES Institute of Technology in Bangalore, India, and prior to attending UCSC, I was a junior research scholar the Indian Institute of Science studying fusion genes in glioblastomas. I’m interested in cancer immunotherapy, machine learning, big data analysis, genomics, and cloud computing. Currently, I’m lead developer on ProTECT, a pipeline to predict potentially therapeutic neo-antigens in cancers. I’m also a developer on the CGL Toil, cgcloud, and s3am projects. My immunology work is used as a part of the Treehouse Childhood Cancer Project, the California Kids Cancer Comparison (CKCC), and I’m an active member of the Cancer Genome Atlas (TCGA) immune responses working group. In my free time, I enjoy travelling, camping, and experimenting with new recipes.

Arthur Rand Team
Arthur Rand Graduate Student Researcher (Mark Akeson Lab – Collaborator)

I earned a B.A. in economics at UC Santa Cruz before working as an organic chemist engineering cyclic peptides to pass through membranes. I discovered my love of computational biology in graduate school, and I’m currently a Ph.D. student in biomedical sciences and engineering at UC Santa Cruz. My interests include DNA sequencing technology, bioinformatics and machine learning, and single-molecule biophysics. I’m currently working on translating ionic current signal into nucleotide bases in systems that reread DNA, algorithms to detect DNA modifications in nanopore sequencing data, variant calling. Outside of research I’m very passionate about bike racing.

Adam Novak Team
Adam Novak Graduate Student Researcher

I am a bioinformatics Ph.D. student at UCSC, where I have been studying since receiving my B.S. in Computer Science and Biology from Harvey Mudd College in 2012. My research interests include the improvement of science practice and the development of effective software tools. For my Ph.D. thesis project, I am attempting to create a graph-based replacement for the human reference genome, and a genomics toolchain that uses it. I aim to reduce the bias inherent in the current single linear human genome reference, which by its nature reifies one particular version of each variable region. When not doing science, I enjoy social dance and reading.

Ian fiddes team
Ian Fiddes Graduate Student Researcher

I’m a Ph.D. student in bioinformatics at UCSC, where I also earned my B.S. in molecular, cell and developmental biology. I’m interested in molecular evolution and comparative genomics, disease-related segmental duplication and I’m currently working on annotating and analyzing assemblies of 17 mouse laboratory strains and the genomic structure of 1q21.1 locus in humans. Outside of research I enjoy cooking, skiing, and road biking.

Joel Armstrong Team
Joel Armstrong Graduate Student Researcher

I’m a Ph.D. student in bioinformatics at UCSC, where I also earned my B.S. in biochemistry and molecular biology. I’m interested in whole-genome alignment, genome rearrangements, comparative genomics, phylogenetics, and machine learning. I’m currently involved in the Cactus and Mouse Genomes projects.

Miten Jain Team
Miten Jain Graduate Student Researcher (Mark Akeson Lab – Collaborator)

I hold an M.S. in bioinformatics from UCSC as well as an M.S. in biotechnology from SUNY Buffalo, and a B.Eng. in biotechnology from the University of Rajasthan, in India. I became interested in health applications of DNA sequencing and computational biology while working as a researcher at a nanotechnology startup. I work on developing nanopore technology for DNA sequencing (long reads, base modifications) and RNA and protein sequencing. Computationally, I work on developing algorithms and software for mapping and alignment, variant calling, and cloud computing. I absolutely love technology and am the lead singer in a contemporary Eastern music band.

Jacob Fiel
Jacob Pfeil Graduate Student Researcher

I am a bioinformatics graduate student at UCSC. I studied biochemistry and math at Dension University. I am interested in genomics, immunotherapy, machine learning, and software engineering. I work on the Precision Immunology pipeline, Toil, and CKCC. In my free time, I enjoy playing bluegrass music and learning languages.

Alden Deran
Alden Deran Graduate Student Researcher

I’ll be starting the PhD program in bioinformatics here in Fall 2016. I’m particularly interested in genome alignment and assembly, graph algorithms, and machine learning, and I’ve been contributing to Cactus, a whole-genome alignment tool. Before getting into bioinformatics I received my undergraduate degree in Physics at UCSC and did a senior thesis on Monte-Carlo simulations of W-boson scattering.

Charles Marcello
Charles Markello Graduate Student Researcher

I’m a Ph.D. student in biomolecular engineering and bioinformatics at UCSC. I hold a B.S. in computer science with a minor in biology from the University of Oregon, and I’ve worked as a special researcher in the Undiagnosed Diseases Program at the NHGRI, and a bioinformatics software developer at Maverix Biomics. I’m interested in bioinformatics, machine learning, data visualization, computer graphics, cloud computing, genetics and comparative genomics.

Currently, I’m working on the BRCA Exchange website for storing and visualizing brca genetic data, diploid graph alignment for improving next-gen-sequencing through the use of pedigree information. Away from UCSC, Charles enjoys rock climbing, skim-boarding, skiing, swing-dancing, and photography.

Audrey Musselman Brown Team
Audrey Musselman-Brown Graduate Student Researcher

I am graduate student researcher in the Biomolecular Engineering department at UCSC with a background in genomics. I hold a BS in Computational and Mathematical Biology from Harvey Mudd College. My research interests include bioinformatics pipelines, cloud computing, machine learning, data sharing, and somatic cancer variants.

Molly Can Zhang
Molly Can Zhang Graduate Student Researcher

I am a PhD student in computer science at UCSC. Previously I earned a MS degree in biochemistry from University of Illinois at Urbana-Champaign and a BS degree in bioengineering from Beijing Institute of Technology in China. Before coming to UCSC, I worked at Genentech, Inc for 2 years on pharmaceutical development of cancer monoclonal antibody drugs. In UCSC CGL I work on BRCA exchange, on web development and predicting variant pathogenicity. I am interested in population genomics, cancer genomics, artificial intelligence, machine learning and tech entrepreneurship. Outside graduate school I like to take advantage of the beautiful natural sceneries in California by go hiking, camping and kayaking. I also like going to South Bay for authentic/spicy Chinese food.

Jordan Eizenga Team
Jordan Eizenga Granduate Student Researcher

I am a PhD student in the Computational Biology and Bioinformatics program. I completed my undergraduate in mathematics and political science at the University of Michigan in 2011. I later became interested in biology and computer science and spent two years studying them in open online courses before starting at UCSC in 2015. My current research interests include nanopore sequencer informatics and using graph structures to represent population genomic variation.

Undergraduate Student Researchers

Jake Narkizian Team
Jake Narkizian Undergraduate Student Researcher

I’m an undergraduate student in the UCSC Jack Baskin School of Engineering, where I expect to earn my B.S. in computer science in 2017. I’m interested in big data analysis, genomics, and cloud computing. I’m currently working on Toil.

Kunal Team
Kunal Dhillon Undergraduate Student Researcher

I’m an undergraduate expecting to receive my B.S. in computer science in 2018. Currently, I’m working on the Global Alliance for Genomics & Health (GA4GH) API. My interests include space exploration, sustainable transportation, and artificial intelligence.

 

Administrative Staff

Nadine Gassner
Nadine Gassner Associate Director Research Development

In partnership with principal investigators, I lead development of a portfolio of Computational Genomics Lab programs.

Nicholas Theodosis
Nick Theodosis Program Coordinator

I’m a grant and program support analyst at UCSC’s Genomics Institute. As program coordinator for our BD2K Center for Big Data in Translational Genomics I provide ancillary support to the Computational Genomics Lab and the BD2K Summer UP program.