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A Million Cancer Genome Warehouse

Technology advances will soon enable us to sequence a person’s genome for less than $1,000, which will lead to an exponential increase in the number of sequenced genomes. The potential of this advance is blunted unless this information is associated with patient clinical data, collected …

ENCODE Project Consortium. A user’s guide to the encyclopedia of DNA elements (ENCODE).

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a …

A cactus graph

Cactus Graphs for Genome Comparisons. Proceedings of RECOMB 2010

We introduce a data structure, analysis and visualization scheme called a cactus graph for comparing sets of related genomes Cactus graphs capture some of the advantages of de Bruijn and breakpoint graphs in one unified framework They naturally decompose the common substructures in a set …