News

Sudan, the last male northern white rhino, who died March 20 at the Ol Pejeta Conservancy in Kenya. CreditSan Diego Zoo Global

Scientists See Promise in Resurrecting These Rhinos That Are Nearly Extinct

May 24, 2018 By Steph Yin When the last male northern white rhinoceros died in March, people mourned the beloved mammal’s step toward extinction. With no members of the subspecies left in the wild and just two females remaining in captivity, it felt like the last …

This is Nola, the last living Northern White Rhinoceroses at the San Diego Zoo Safari Park. Credit:San Diego Zoo Global

Imminent extinction of northern white rhinoceros motivates genetic recovery efforts

May 24, 2018 By Dana Macciola COLD SPRING HARBOR LABORATORY PRESS Earlier this year, the last remaining male Northern White Rhinoceros (NWR) died in captivity, nearly cementing the fate of this subspecies for extinction. In the wild, continuing threats of poaching, habitat destruction, and small population …

The MinION DNA sequencer © OXFORD NANOPORE

Handheld device sequences human genome

By James Gallagher  BBC News  29 January 2018 Scientists have used a device that fits in the palm of the hand to sequence the human genome. They say the feat, detailed in the journal Nature Biotechnology, opens up exciting possibilities for using genetics in routine …

Map Your Genome at Home with Cell-phone Sized Human DNA Sequencer

By Kastalia Medrano 1/29/18 Newsweek The most extensive and detailed human genome sequence yet has been assembled using a hand-held device roughly the size of a cell phone. An international team of scientists working at a lab at the University of California, Santa Cruz, created …

Bioinformatics experts see cloud-based computing and data storage as the most effective way to manage and use rapidly growing biomedical datasets. (Photo by Elena Zhukova)

Bioinformatics leaders partner to build platform for NIH Data Commons

UC Santa Cruz Genomics Institute, University of Chicago, and the Broad Institute will create the Commons Alliance Platform with funding from the National Institutes of Health November 06, 2017 By Tim Stephens The life sciences are in the midst of a data revolution. Technologies such as …

A Data Biosphere for Biomedical Research

By Benedict Paten We, the authors listed below, are privileged to be part of the growing global community bringing data and life science together. Our groups have been working together in overlapping combinations during the past two years to drive the creation of data commons …

prototype-visualization-of-a-genomic-variation-graph
This prototype visualization of a genomic variation graph zooms in on portions of the NOTCH2 gene, an important gene for development. The colored bands represent 5 different variants of the gene, with rectangular shapes representing nodes (shared DNA sequences) and the colored ribbons between nodes representing paths/edges (not sequences). In the top panel, introns are shaded out (at right and left) while the solid colors represent exons 4 and 5. The exons are shown in increasingly greater detail in the bottom two panels. The visualization tool can also provide an intuitive graphical view of inversions, as shown in the green and red loops in the simulated example to the right. Images courtesy of Wolfgang Beyer, software developer for the Computational Genomics Laboratory at the University of California, Santa Cruz.

Visualizing Human Genome Variation

A comprehensive, genomic variation graph offers an intuitive view of how human genomes vary Biomedical Computation Review | By Katharine Miller Humans share 99.5 percent of their DNA sequence, but that still leaves plenty of variation to go around. To get a handle on which …